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Synchronous bilateral renal cell carcinomas with differing histologies.

Ryu Shigehisa¹, Takashi Karashima¹, Shu Kobayashi¹

¹Department of Urology Kochi Medical School Nankoku Japan.

IJU Case Reports

|September 11, 2020

Summary

This report details a rare case of synchronous bilateral renal tumors. The patient presented with clear cell renal cell carcinoma in one kidney and mucinous tubular and spindle cell carcinoma in the other.

Keywords:

bilateral clear cell renal cell carcinoma mucinous tubular and spindle cell carcinoma renal cell carcinoma synchronous

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Area of Science:

Nephrology
Oncology
Pathology

Background:

Bilateral renal cell carcinomas (RCCs) with distinct histological subtypes are exceptionally rare in medical literature.
Synchronous occurrence of different histological types of RCC in both kidneys presents a unique diagnostic and therapeutic challenge.

Observation:

A 62-year-old male patient presented with bilateral renal tumors exhibiting varied imaging characteristics on contrast-enhanced computed tomography and magnetic resonance imaging.
Surgical intervention involved partial resection of both renal tumors.

Findings:

Histopathological and immunohistochemical analyses confirmed clear cell renal cell carcinoma (ccRCC) in the left kidney.
The right renal tumor was diagnosed as mucinous tubular and spindle cell carcinoma (MTSCC).

Implications:

This case represents the first documented instance of simultaneous ccRCC and MTSCC in bilateral kidneys.
Understanding the synchronous presentation of diverse RCC subtypes is crucial for accurate diagnosis, treatment planning, and prognosis in renal oncology.