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Updated: Dec 9, 2025

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
Published on: May 7, 2012
Letermovir for the compassionate therapeutic use of cytomegalovirus infection
Lorenz Schubert1, Lisa Fisecker1, Florian Thalhammer1
1Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University Vienna, Vienna, Austria.
Purpose:
Data on the efficacy, dosing and safety of letermovir for the compassionate therapeutic use of CMV infections are limited.
Methods:
Clinical and virological efficacy of letermovir was assessed in a retrospective single-centre study of patients who received letermovir for the compassionate therapeutic use of CMV infections.
Results:
Letermovir initiation yielded prompt treatment response in 7 out of 9 patients (77.7%).
Conclusion:
Letermovir may be an effective and well tolerated option in the compassionate treatment of CMV infections, although recurrence of CMV and emergence of resistance may be issues.
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