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Related Experiment Video

Updated: Dec 9, 2025

Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms

Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms

Published on: July 26, 2024

Mouse models for abdominal aortic aneurysm.

Jonathan Golledge^1,2,3, Smriti Murali Krishna^1,2,3, Yutang Wang⁴

¹Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia.

British Journal of Pharmacology

|September 11, 2020

Summary

This summary is machine-generated.

Abdominal aortic aneurysm (AAA) rupture is a major cause of death. This review highlights mouse models and research into inflammation, cell turnover, long non-coding RNAs, and thrombosis, aiming to develop effective drug therapies for AAA growth.

Keywords:

abdominal aortic aneurysm mouse models pathology

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Last Updated: Dec 9, 2025

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Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Published on: March 8, 2019

Area of Science:

Cardiovascular Research
Translational Medicine
Pharmacology

Background:

Abdominal aortic aneurysm (AAA) rupture causes significant mortality.
Current surgical repair has limitations and risks.
Conservative management of small AAAs allows continued growth and rupture risk.

Purpose of the Study:

To review commonly used mouse models for AAA.
To highlight recent research findings in AAA pathogenesis.
To identify potential targets for drug therapies to slow AAA growth.

Main Methods:

Review of existing literature on AAA mouse models.
Analysis of research identifying key pathways in AAA development.
Examination of evidence for non-coding RNAs and thrombosis in AAA.

Main Results:

Mouse models are crucial for studying AAA.
Inflammation and cell turnover are key in AAA pathogenesis.
Long non-coding RNAs and thrombosis also play roles in aneurysm pathology.

Conclusions:

Further research in clinically relevant models is needed.
Translating findings from preclinical models can lead to effective AAA drugs.
Development of drug therapies is essential for managing AAA growth.