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Related Experiment Video

Updated: Dec 9, 2025

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
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General top-down strategy for generating single-digit nanodiamonds for bioimaging.

Tongming Chen1, Fei Yang1, Pu Liu1

  • 1State Key Laboratory of Optoelectronic Materials and Technologies, Nanotechnology Research Center, School of Materials Science & Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510275, People's Republic of China.

Nanotechnology
|September 11, 2020
PubMed
Summary

Researchers developed a new method to create tiny, fluorescent nanodiamonds. This technique produces stable, single-digit nanodiamonds suitable for advanced bioimaging applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biotechnology

Background:

  • Synthesizing nanodiamonds smaller than 4 nm without aggregation is difficult.
  • Colloidal solutions of single-digit nanodiamonds are challenging to produce in large volumes.

Purpose of the Study:

  • To develop a facile top-down strategy for fabricating monodisperse colloidal fluorescent nanodiamonds.
  • To achieve tunable, high-performance fluorescence bioimaging using these nanodiamonds.

Main Methods:

  • Utilized laser ablation in liquids on commercial diamond microcrystals in an ambient environment.
  • Investigated a mechanism involving conversion to disordered carbon nanoparticles then to nanodiamonds under laser irradiation.
  • Employed in situ covalent linking of ester and ketone groups on nanodiamond surfaces.

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Last Updated: Dec 9, 2025

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Main Results:

  • Successfully fabricated monodisperse colloidal fluorescent nanodiamonds with a mean size of 3.6 nm.
  • Demonstrated a mechanism for nanodiamond formation via laser-induced phase conversion.
  • Achieved tunable fluorescence bioimaging capabilities through surface functionalization.

Conclusions:

  • Single-digit fluorescent nanodiamonds can be generated from colloidal solutions using this method.
  • The developed strategy offers a promising route for producing high-quality nanodiamonds for bioimaging.
  • Surface functionalization allows for tailored fluorescence properties for specific bioimaging applications.