Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The Ro/SS-A antigen-antibody system].

W J Mayet1, M Bachmann, E Hermann

  • 1I. Medizinische Klinik, Universität Mainz.

Zeitschrift Fur Rheumatologie
|March 1, 1988
PubMed
Summary

Ro/SS-A antibodies are crucial for evaluating lupus patients with photosensitive skin. These antibodies are also linked to Sjögren

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Possible Significance of Bronchoalveolar Lavage Cytology at Initial Diagnosis and Follow-up of Lung Cancer].

Pneumologie (Stuttgart, Germany)·2017
Same author

Patterns of care in recurrent glioblastoma in Switzerland: a multicentre national approach based on diagnostic nodes.

Journal of neuro-oncology·2015
Same author

Clinical and pathological nodal staging score for urothelial carcinoma of the bladder: an external validation.

World journal of urology·2013
Same author

A rare anomaly of the anterior communicating artery complex hidden by a large broad-neck aneurysm and disclosed by three-dimensional rotational angiography.

Acta neurochirurgica·2008
Same author

Therapeutic drug monitoring of tricyclic antidepressants: how does it work under clinical conditions?

Pharmacopsychiatry·2003
Same author

CpG motifs induce Langerhans cell migration in vivo.

International immunology·2000

Area of Science:

  • Immunology
  • Rheumatology
  • Dermatology

Background:

  • The Ro/SS-A antibody system, identified in 1969, is significant in diagnosing autoimmune diseases.
  • Ro antibodies are associated with lupus erythematosus, particularly those with photosensitive skin lesions.
  • These antibodies are also observed in primary Sjögren's syndrome, neonatal lupus erythematosus, and congenital heart block.

Purpose of the Study:

  • To review current knowledge on the Ro-antigen-antibody system.
  • To highlight the clinical importance of Ro/SS-A antibodies in specific patient populations.
  • To discuss the potential pathogenic role of Ro antibodies based on recent biochemical data.

Main Methods:

  • Literature review of studies concerning the Ro-antigen-antibody system.
  • Summary of clinical findings associated with Ro/SS-A antibodies.
  • Inclusion of recent biochemical characterization data.

Main Results:

  • Ro/SS-A antibodies are important in evaluating lupus patients with photosensitive cutaneous lesions.
  • Ro antibodies are present in primary Sjögren's syndrome, neonatal lupus erythematosus, congenital heart block, and ANA-negative lupus erythematosus.
  • Biochemical data suggest a potential direct pathogenic effect of these antibodies.

Conclusions:

  • The Ro/SS-A antibody system is a key diagnostic marker in specific autoimmune conditions.
  • Further research into the pathogenic mechanisms of Ro antibodies is warranted.
  • Understanding the Ro-antigen-antibody system aids in the comprehensive evaluation of patients with lupus and related disorders.

Related Experiment Videos