Solid-State Radical C-H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials
Yadong Pang1, Joo Won Lee2, Koji Kubota1,2
1Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan.
Abstract:
The application of piezoelectricity for the generation of trifluoromethyl (CF3 ) radicals is reported together with the development of a method for the mechanochemical C-H trifluoromethylation of aromatic compounds. As compared to conventional solution-based approaches, this mechanoredox C-H trifluoromethylation enables cleaner and more sustainable access to a wide range of trifluoromethylated N-heterocycles and peptides, which are important structural motifs in modern drug discovery. This study thus represents an important milestone for future applications of mechanoredox systems to medicinal and pharmaceutical science.
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