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Relation between left atrial structure and lacunar infarction in patients with hypertension

Ting Sun1, Tong Xie1,2, Alian Zhang1

  • 1Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China.

Aging
|September 11, 2020
PubMed

Insights

Left atrial enlargement, including left atrial volume (LAV) and diameter ratio (LAD/LVD), predicts lacunar infarction (LACI) risk in hypertensive patients. These measurements can identify individuals vulnerable to stroke.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Imaging

Background:

  • Lacunar infarction (LACI) increases the risk of major stroke.
  • Hypertension is a known risk factor for LACI and is associated with left atrial enlargement.
  • Identifying high-risk hypertensive patients for LACI is crucial for preventative strategies.

Purpose of the Study:

  • To investigate if left atrium size is an independent predictor of LACI in patients with hypertension.
  • To assess the predictive value of left atrial diameter (LAD), left atrial volume (LAV), and the LAD/left ventricular diameter (LAD/LVD) ratio for LACI.

Main Methods:

  • Cross-sectional analysis of 365 hypertensive patients.
  • Data collected from Shanghai Ninth People's Hospital between January 2016 and January 2017.
  • Receiver Operating Characteristic (ROC) curve analysis to determine predictive accuracy.

Main Results:

  • Left atrial diameter (LAD), left atrial volume (LAV), and LAD/LVD ratio were significantly associated with LACI in hypertensive patients.
  • Area Under the Curve (AUC) for LAV was 0.737 and for LAD/LVD was 0.784.
  • Optimal cut-off for LAV was 30.14 (sensitivity 72%, specificity 63%), and for LAD/LVD was 0.757 (sensitivity 77%, specificity 70%).

Conclusions:

  • Left atrial volume (LAV) and the LAD/LVD ratio are important indicators for LACI in hypertensive individuals.
  • These echocardiographic measurements can serve as independent risk factors for predicting LACI in hypertensive patients.

Keywords:
hypertensionlacunar infarctleft atrium volumeratio of left atrial diameter to left ventricular diameter

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