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Related Experiment Video

Updated: Dec 9, 2025

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats
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SenseBack - An Implantable System for Bidirectional Neural Interfacing.

Ian Williams, Emma Brunton, Adrien Rapeaux

    IEEE Transactions on Biomedical Circuits and Systems
    |September 11, 2020
    PubMed
    Summary
    This summary is machine-generated.

    The SenseBack system offers a wireless, reprogrammable 32-channel neural interface for chronic in-vivo electrophysiology in small animals. This flexible device enables advanced research by recording and stimulating neural signals post-implantation.

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    An Implantable System For Chronic In Vivo Electromyography
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    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Implantable Devices

    Background:

    • Chronic in-vivo neurophysiology requires miniaturized, remotely powered neural interfaces.
    • Current interfaces lack post-implantation power and flexibility.
    • This limits complex, adaptive electrophysiology studies in freely behaving animals.

    Purpose of the Study:

    • To introduce the SenseBack system, a novel wireless 32-channel bidirectional neural interface.
    • To enable chronic peripheral electrophysiology in freely behaving small animals with enhanced flexibility.
    • To overcome limitations of existing neural interfaces for advanced in-vivo research.

    Main Methods:

    • Developed a fully implantable, post-implantation reprogrammable wireless 32-channel device.
    • Demonstrated transcutaneous power delivery and Bluetooth 5 data communication.
    • Validated recording capabilities (20 kHz sampling, adjustable gain/filtering) and high-voltage bipolar stimulation (20 V compliance, 315 µA current).

    Main Results:

    • The SenseBack system successfully recorded neural signals and performed bipolar stimulation in ex-vivo and in-vivo preparations.
    • Achieved wireless data transmission and remote power delivery.
    • Demonstrated the system's flexibility, including post-encapsulation reprogramming.

    Conclusions:

    • The SenseBack system represents a significant advancement in neural interfacing for small animal research.
    • Its high channel count, flexibility, and wireless capabilities enable complex, adaptive in-vivo electrophysiology studies.
    • This platform is expected to facilitate a wide range of future research in freely behaving animals.