Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cellular mechanisms in congestive heart failure.

¹Department of Medicine, University of Connecticut, Farmington 06032.

The American Journal of Cardiology

|July 11, 1988

Summary

The failing heart is energy-depleted, suggesting therapies increasing energy demand may harm patients with congestive heart failure (CHF). Improving energy balance could improve CHF prognosis and patient survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Phylogeny and historical biogeography of neotropical catfishes Trichomycterus (Siluriformes: Trichomycteridae) from eastern Brazil.

Molecular phylogenetics and evolution·2023

Same author

HEART FAILURE.

A listing of research in the cardiovascular field·2014

Same author

Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.

Genes, brain, and behavior·2012

Same author

Scientific insights from clinical studies of converting-enzyme inhibitors in the failing heart.

Trends in cardiovascular medicine·2011

Same author

Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism.

Neuroscience·2010

Same author

Mortality and cancer morbidity in a cohort of Canadian petroleum workers.

Occupational and environmental medicine·2003

Area of Science:

Cardiology
Biochemistry
Heart Failure Pathophysiology

Background:

Substantial evidence suggests the failing heart exists in an energy-depleted state.
This energy imbalance has significant implications for managing congestive heart failure (CHF).

Purpose of the Study:

To explore the implications of myocardial energy imbalance in congestive heart failure (CHF).
To hypothesize therapeutic strategies based on cardiac energetics for improved CHF patient outcomes.

Main Methods:

Review of existing evidence on cardiac energetics in heart failure.
Analysis of the potential impact of therapeutic interventions on myocardial energy metabolism.

Main Results:

Therapies increasing myocardial energy demand (vasoconstrictors, positive inotropes) may worsen heart function and promote arrhythmias.
Therapies improving energy balance (vasodilators, reduced inotropic drive) may prolong survival in CHF patients.

Conclusions:

Understanding cardiac energetics is crucial for developing effective long-term therapies for CHF.
Future research should focus on evaluating energy-modulating strategies in controlled clinical trials for congestive heart failure.

Related Experiment Videos