Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Arrhythmias, catecholamines and electrolytes.

J G Cleland1, H J Dargie

  • 1Western Infirmary, Glasgow, Scotland.

The American Journal of Cardiology
|July 11, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pragmatic diagnostic and therapeutic algorithms to optimize new potassium binder use in cardiorenal disease.

Pharmacological research·2022
Same author

The association between blood groups and COVID-19 infection: a study from the UK Biobank.

Journal of internal medicine·2020
Same author

Tumour biomarkers: association with heart failure outcomes.

Journal of internal medicine·2020
Same author

Added value of frailty and social support in predicting risk of 30-day unplanned re-admission or death for patients with heart failure: An analysis from OPERA-HF.

International journal of cardiology·2018
Same author

Novel endotypes in heart failure: effects on guideline-directed medical therapy.

European heart journal·2018
Same author

Determinants and clinical outcome of uptitration of ACE-inhibitors and beta-blockers in patients with heart failure: a prospective European study.

European heart journal·2017
Same journal

Real-World Effectiveness and Tolerability of Sacubitril/Valsartan in Octogenarian Patients With Heart Failure: Results From the PARACHUTER Study.

The American journal of cardiology·2026
Same journal

ECG-Guided Conduction Pathways as a Lever to Shorten Post-TAVI Hospitalization.

The American journal of cardiology·2026
Same journal

Cystatin-C versus creatinine and kidney function in heart failure with preserved ejection fraction: a SOGALDI-PEF analysis.

The American journal of cardiology·2026
Same journal

Balloon-expandable versus Self-expanding Valves in Patients with Small Aortic Annuli Undergoing Transcatheter Aortic Valve Replacement.

The American journal of cardiology·2026
Same journal

Drug-Coated Balloons versus Drug-Eluting Stents following Coronary Atherectomy in Severely Calcified Lesions: A Systematic Review and Meta-Analysis.

The American journal of cardiology·2026
Same journal

Prehospital Statin Therapy and Outcomes in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

The American journal of cardiology·2026
See all related articles

Patients with heart failure and left ventricular dysfunction often experience sudden cardiac death due to ventricular arrhythmias. Angiotensin-converting enzyme inhibitors may reduce these arrhythmias by correcting neuroendocrine and electrolyte imbalances.

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Arrhythmia Studies

Background:

  • Prognosis for heart failure (HF) patients with left ventricular dysfunction is poor.
  • Sudden cardiac death is a significant cause of mortality in HF, often preceding refractory heart failure.
  • Ventricular arrhythmias are highly prevalent in HF patients and are key predictors of mortality.

Purpose of the Study:

  • To investigate the relationship between neuroendocrine activation, electrolyte abnormalities, and ventricular arrhythmias in heart failure.
  • To assess the impact of angiotensin-converting enzyme (ACE) inhibitors on these factors and arrhythmia frequency.

Main Methods:

  • Ambulatory electrocardiography to assess ventricular arrhythmias.
  • Measurement of serum and total body potassium levels.

Related Experiment Videos

  • Evaluation of renin-angiotensin system activation and noradrenaline levels.
  • Analysis of neuroendocrine and electrolyte changes in patients treated with ACE inhibitors.

    • Main Results:

    • Reduced serum and total body potassium were observed in treated HF patients, inversely related to renin-angiotensin system activation.
    • Renin and noradrenaline levels were directly correlated and inversely related to arterial pressure.
    • ACE inhibitor treatment showed a trend towards reversing these neuroendocrine and electrolyte abnormalities.
    • ACE inhibitors reduced the frequency of ventricular arrhythmias in these patients.

    Conclusions:

    • Ventricular arrhythmias are a critical predictor of mortality in heart failure patients with left ventricular dysfunction.
    • Neuroendocrine and electrolyte abnormalities, particularly low potassium and activated renin-angiotensin system, are linked to arrhythmias.
    • ACE inhibitors show potential in mitigating these abnormalities and reducing ventricular arrhythmia burden, warranting further investigation into their impact on sudden cardiac death.