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Analgesic nephropathy.

W L Henrich1

  • 1University of Texas, Southwestern Medical Center, Dallas.

The American Journal of the Medical Sciences
|June 1, 1988
PubMed
Summary
This summary is machine-generated.

Chronic analgesic use, especially phenacetin and nonsteroidal anti-inflammatory drugs, can cause kidney damage. This review examines analgesic nephropathy and related kidney disorders from a clinical viewpoint.

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Area of Science:

  • Nephrology
  • Clinical Pharmacology

Background:

  • Analgesic nephropathy is a recognized clinical issue linked to chronic analgesic use.
  • Historically, phenacetin-containing analgesics were associated with chronic renal insufficiency.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are now recognized as a cause of distinct kidney syndromes.

Purpose of the Study:

  • To review the clinical aspects of analgesic nephropathy.
  • To discuss kidney disorders associated with both phenacetin and NSAIDs.

Main Methods:

  • This is a review article.
  • Clinical data and literature on analgesic nephropathy were analyzed.

Main Results:

  • Chronic consumption of analgesics, including phenacetin and NSAIDs, is associated with kidney damage.

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  • NSAIDs can induce various clinical syndromes affecting the kidneys.

    • Conclusions:

    • Analgesic nephropathy remains a significant clinical problem.
    • Understanding the clinical presentation of NSAID-induced kidney disorders is crucial for patient care.