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Meta-analysis of Cardiovascular Events and Related Biomarkers Comparing Survivors Versus Non-survivors in Patients

Saeed Shoar1, Fatemeh Hosseini2, Mohammad Naderan3

  • 1Department of Clinical Research, ScientificWriting Corporation, Houston, TX.

The American Journal of Cardiology
|September 11, 2020
PubMed

Insights

COVID-19 patients with cardiovascular disease risk factors, severe symptoms like dyspnea, and elevated biomarkers face higher mortality. Early identification of these factors is crucial for predicting fatal outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • The emergence of COVID-19 has been associated with cardiovascular complications and increased mortality.
  • Understanding the link between cardiovascular disease and COVID-19 outcomes is critical for patient management.

Purpose of the Study:

  • To compare cardiovascular events and biomarkers between COVID-19 survivors and non-survivors.
  • To identify predictors of mortality in hospitalized COVID-19 patients.

Main Methods:

  • A systematic online search of Medline/PubMed was conducted.
  • 12 comparative cohort studies pooling data from 1,845 hospitalized COVID-19 patients were analyzed.
  • Cardiovascular events, biomarkers, and clinical presentations were compared between survivors and non-survivors.

Main Results:

  • The overall COVID-19 mortality rate was 17.6%, with men over 50 at higher risk.
  • Comorbidities like hypertension, diabetes, smoking, and prior cardiovascular disease significantly contributed to mortality.
  • Elevated biomarkers (LDH, CK, BNP, troponin I) and clinical signs (dyspnea, tachycardia, hypoxemia) were associated with increased mortality.

Conclusions:

  • Severe clinical presentation and elevated cardiovascular biomarkers in COVID-19 patients with risk factors predict mortality.
  • Adverse cardiovascular events such as shock, arrhythmias, and myocardial injury precede death in high-risk patients.
  • This study highlights the importance of monitoring cardiovascular health in COVID-19 patients to mitigate mortality risk.

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