Differentiating the effects of ambient fine and coarse particles on mortality from cardiopulmonary diseases: A nationwide multicity study

Both inhalable particles (PM₁₀) and fine particles (PM_2.5) are regulated in various countries mainly due to their adverse health effects. However, there is increasing evidence that PM_2.5 might be responsible for these effects and coarse particles (PM_c) plays little role in adverse health effects, if so, it might be not necessary to monitor PM₁₀.

In this study, we conducted a time-series analysis using a generalized additive model to explore the effects of PM_2.5, PM_c, and PM₁₀ on mortality from ischemic heart disease (IHD) and chronic obstructive pulmonary disease (COPD) in 96 Chinese cities during 2013-2016. The mortality number and attributable fraction were further estimated using the national air quality standard and WHO's guideline as the reference.

We observed significant effects of PM_2.5 on IHD and COPD mortality; each 10 ug/m³ increase in lag₀₁ PM_2.5 was associated with a 0.26% (95% CI: 0.17%, 0.34%) increase in IHD mortality and a 0.19% (95% CI: 0.09%, 0.29%) increase in COPD mortality. We also found significant effects of PM_c and PM₁₀ on mortality from IHD and COPD, but the magnitudes of effects were weaker than those of PM_2.5. The results were robust when adjusting for co-pollutants and altering model parameters. We further estimated that about 1.27% (95% CI: 0.29%, 2.30%) of IHD mortality and 1.25% (95% CI: 0.08%, 2.46%) of COPD mortality could be attributable to PM_2.5 exposure using WHO's guideline (25 ug/m³) as a reference, corresponding to 15,337 (95% CI: 3,375, 27,842) mortalities from IHD and 5,653 (95% CI: 379, 11,152) COPD mortalities in the 96 cities. Across all of China, almost fifty thousand cases of IHD mortality and twenty thousand cases of COPD mortality might be avoidable if the PM_2.5 concentration declined to the WHO guideline.

Our study indicates that short-term exposure to PM_2.5 could be an important risk factor of mortality from IHD and COPD, and substantial cardiopulmonary mortality could be avoidable by reducing daily PM_2.5 concentrations. It is nonnegligible to consider the role of PM_c in triggering in cardiopulmonary mortality. And it could be necessary to continue monitoring PM₁₀ in the study regions due to the adverse effects of PM_c.