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Smart ECM-Based Electrospun Biomaterials for Skeletal Muscle Regeneration
Sara Politi1,2, Felicia Carotenuto1,2,3, Antonio Rinaldi4
1Department of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, CR Frascati, 00044 Rome, Italy.
Nanomaterials (Basel, Switzerland)
|September 12, 2020
Summary
Developing advanced biomaterials for skeletal muscle tissue engineering requires mimicking the body's natural extracellular matrix. This study explores biofunctional composite electrospun materials, including decellularized extracellular matrix, for enhanced tissue regeneration.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Skeletal muscle tissue engineering faces challenges in creating biomimetic systems for optimal regeneration.
- Electrospinning produces nanoscale fibers mimicking the natural extracellular matrix structure.
- Composite materials from natural and synthetic polymers enhance cell function and adhesion.
Purpose of the Study:
- To review current methods for creating biofunctional composite electrospun biomaterials.
- To propose a novel design for skeletal muscle tissue regeneration.
Main Methods:
- Utilizing electrospinning to create composite biomaterials.
- Incorporating decellularized extracellular matrix (dECM) into electrospun constructs.
- Exploring "click" chemistry for biomolecule functionalization.
Main Results:
- Composite electrospun materials show potential for supporting cell adhesion and function.
- Decellularized extracellular matrix (dECM) retains biological cues beneficial for regeneration.
- "Click" chemistry offers a modular and efficient approach to biofunctionalization.
Conclusions:
- Biofunctional composite electrospun materials, especially those incorporating dECM and functionalized via "click" chemistry, hold significant promise for skeletal muscle tissue engineering.
- Further design and development are needed to optimize these materials for clinical applications in skeletal muscle regeneration.
