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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Related Experiment Video

Updated: Dec 9, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

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Nucleic Acid-Based Approaches for Tumor Therapy.

Simone Hager1, Frederic Julien Fittler2, Ernst Wagner1

  • 1Department of Chemistry and Pharmacy, Ludwig-Maximilians-University (LMU), 81377 Munich, Germany.

Cells
|September 12, 2020
PubMed
Summary

Nucleic acid-based drugs, including mRNA vaccines and RNA interference, are advancing cancer treatment by enhancing anti-tumor immune responses. Combination therapies with these agents and checkpoint inhibitors offer a promising strategy against tumor immune evasion.

Keywords:
adjuvantantigendendritic cellimmunotherapynanoparticlenucleic acidstransgenetumor

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Area of Science:

  • Oncology
  • Immunotherapy
  • Molecular Biology

Background:

  • Checkpoint inhibitors have established immunotherapy's efficacy in cancer treatment.
  • Nucleic acid-based drugs, delivered via nano-carriers, are emerging as potent anti-tumor agents.

Purpose of the Study:

  • To provide a comprehensive review of nucleic acid-based therapeutics for cancer treatment.
  • To explore various applications of nucleic acids in cancer immunotherapy.

Main Methods:

  • Review of current literature on nucleic acid-based cancer therapies.
  • Categorization of therapeutic strategies including mRNA/DNA vaccines, molecular adjuvants, RNA interference (RNAi), and gene therapy.

Main Results:

  • Nucleic acids can be used for anti-tumor vaccines, immune modulation, and cell reprogramming.
  • Strategies include mRNA/DNA vaccines for T cell responses, RNAi for inhibiting regulatory cells, and gene transfer for modifying immune cells and the tumor microenvironment.

Conclusions:

  • Nucleic acid-based drugs represent a significant advancement in cancer therapy.
  • Combination treatments involving nucleic acids, conventional regimens, and checkpoint inhibitors are crucial for overcoming tumor immune evasion.