Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non-steroidal anti-inflammatory nephrotoxicity.

R Maniglia1, A B Schwartz, S Moriber-Katz

  • 1Department of Pathology, Hahnemann University School of Medicine, Philadelphia, PA 19102.

Annals of Clinical and Laboratory Science
|May 1, 1988
PubMed
Summary

Non-steroidal anti-inflammatory drugs (NSAIDs) can cause kidney damage, a condition known as NSAID nephrotoxicity. This study found interstitial nephritis in eight out of nine patients who experienced renal dysfunction while taking NSAIDs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autochthonous Thelazia callipaeda Infection in Dog, New York, USA, 2020.

Emerging infectious diseases·2021
Same author

Temporally Segmented Directionality in the Motor Cortex.

Cerebral cortex (New York, N.Y. : 1991)·2017
Same author

Ten-dimensional anthropomorphic arm control in a human brain-machine interface: difficulties, solutions, and limitations.

Journal of neural engineering·2014
Same author

Outcomes in HIV-infected adults with tuberculosis at clinics with and without co-located HIV clinics in Botswana.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2013
Same author

State-space control of prosthetic hand shape.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2013
Same author

Statistical Signal Processing and the Motor Cortex.

Proceedings of the IEEE. Institute of Electrical and Electronics Engineers·2011

Area of Science:

  • Nephrology
  • Pharmacology
  • Internal Medicine

Background:

  • Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for their pain-relieving and anti-inflammatory effects.
  • However, NSAIDs are associated with potential kidney damage (nephrotoxicity).

Purpose of the Study:

  • To investigate cases of NSAID-induced nephrotoxicity.
  • To review the mechanisms underlying NSAID nephrotoxicity.

Main Methods:

  • Retrospective case study of 13 patients with abnormal urinalysis or declining renal function while on NSAIDs.
  • Renal biopsies were performed on nine patients.

Main Results:

  • Eight of the nine patients who underwent renal biopsy showed interstitial nephritis.

Related Experiment Videos

  • The study identified NSAID nephrotoxicity in patients using fenoprofen, naproxen, ibuprofen, sulindac, tolmetin, and indomethacin.

    • Conclusions:

    • NSAIDs can cause interstitial nephritis, leading to renal dysfunction.
    • Further research into NSAID nephrotoxicity mechanisms is warranted.