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Updated: Dec 9, 2025
08:49
Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
Published on: May 11, 2018
9.8K
International experience using a durable, centrifugal-flow ventricular assist device for biventricular support
Silvana Marasco1, André R Simon2, Steven Tsui3
1Cardiothoracic Department, Alfred Hospital, Melbourne, Victoria, Australia.
Summary
Biventricular assist device (BiVAD) using the HeartWare HVAD System shows similar survival rates regardless of the right ventricular assist device (RVAD) implant location or timing. Common adverse events included bleeding, infection, and respiratory failure.
Area of Science:
- Cardiology
- Medical Devices
- Surgical Outcomes
Background:
- Heart transplantation is limited by donor organ scarcity.
- Advanced biventricular failure necessitates robust cardiac support.
- Biventricular assist devices (BiVAD) offer a solution for optimal cardiac output and end-organ perfusion.
Purpose of the Study:
- To evaluate the outcomes of the HeartWare HVAD System (HVAD) used in a biventricular configuration.
- To compare survival rates based on RVAD implant location (right ventricle vs. right atrium).
- To assess the impact of RVAD implantation timing (primary vs. staged) on adverse event profiles and survival.
Main Methods:
- Retrospective study of 93 patients implanted with HVAD as BiVAD (2009-2017) across 12 centers.
- Kaplan-Meier survival estimates were calculated.
- Adverse event (AE) profiles were compared based on RVAD implant location and implantation timing.
Main Results:
- One-year and two-year survival rates were 56% and 47%, respectively.
- Survival was not significantly different between RVAD implant locations (RV vs. RA).
- Survival was also independent of primary versus staged RVAD implantation.
Conclusions:
- Similar survival outcomes were observed for primary versus staged HVAD BiVAD implants.
- RVAD implant location (RV or RA) did not influence adverse event profiles.
- The HeartWare HVAD System in a BiVAD configuration demonstrates comparable outcomes across different implantation strategies.
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