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Updated: Dec 9, 2025

Mouse In Vivo Placental Targeted CRISPR Manipulation
Published on: April 14, 2023
Conservative approach: Intentional retention of the placenta
Loïc Sentilhes1, Gilles Kayem2, Aurélien Mattuizzi1
1Department of Obstetrics and Gynaecology, Bordeaux University Hospital, Bordeaux, France.
Abstract:
Intentional retention of the placenta (IRP), or 'conservative' treatment or management, entails opening the uterus, delivering the baby, tying and cutting the umbilical cord at its placental insertion site, leaving the placenta in the uterus and waiting for its complete spontaneous resorption in women with placenta accreta spectrum (PAS). The uterine preservation rate with this approach is about 78%, and severe maternal morbidity about 6%; these rates are respectively lower and higher in subgroups of women with placenta percreta. IRP has become a recommended option for women with PAS reluctant to undergo caesarean-hysterectomy and wanting to preserve their fertility, after appropriate information about the uterine preservation rate, but also the risk of a subsequent emergency hysterectomy due to unpredictable haemorrhage and/or infection, and the need for follow-up with regular visits for several months. Some authorities also recommend IRP when hysterectomy is at very high risk of surgical complications.

