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Related Experiment Video

Updated: Dec 9, 2025

Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling
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Efficient high-throughput SARS-CoV-2 testing to detect asymptomatic carriers.

Noam Shental1, Shlomia Levy2,3, Vered Wuvshet2,3

  • 1Department of Computer Science, The Open University of Israel, Ra'anana, Israel. angel@bgu.ac.il shental@openu.ac.il thertz@bgu.ac.il.

Science Advances
|September 12, 2020
PubMed
Summary
This summary is machine-generated.

Pooling-Based Efficient SARS-CoV-2 Testing (P-BEST) increases diagnostic capacity by pooling samples. This method efficiently identifies asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carriers, reducing costs and test numbers.

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Area of Science:

  • Virology
  • Public Health
  • Biotechnology

Background:

  • Asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections pose a significant challenge to disease control.
  • Viral shedding before symptom onset necessitates enhanced diagnostic capabilities to prevent transmission.

Purpose of the Study:

  • To develop an efficient method for mass SARS-CoV-2 testing to increase diagnostic capacity.
  • To reduce the cost and complexity of large-scale SARS-CoV-2 screening.

Main Methods:

  • Developed Pooling-Based Efficient SARS-CoV-2 Testing (P-BEST), a combinatorial pooling strategy utilizing compressed sensing.
  • Assigned individual samples into multiple pools for a single round of testing.
  • Screened 1115 healthcare workers using 144 tests by pooling 384 samples into 48 pools.

Main Results:

  • P-BEST achieved an eightfold increase in testing efficiency.
  • The method resulted in an eightfold reduction in test costs.
  • Successfully identified up to five positive SARS-CoV-2 carriers within pooled samples.

Conclusions:

  • P-BEST offers an efficient and cost-effective solution for increasing SARS-CoV-2 testing capacity.
  • The method is easily implementable in diagnostic laboratories for widespread screening.
  • P-BEST aids in identifying asymptomatic carriers, crucial for controlling disease spread.