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Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus.

Soyoun Kim1,2, Dajung Jung1,3, Sébastien Royer4,5

  • 1Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.

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|September 12, 2020
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Summary

Granule cells (GCs) in the dentate gyrus slowly develop place cells with experience, transforming sparse object representations into evenly dispersed spatial fields. Mossy cells (MCs) help homogenize these representations.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Place cells in the hippocampus map environments through spatially selective firing.
  • The developmental process of these spatial representations with experience is not well understood.

Purpose of the Study:

  • To investigate how spatial representations in the dentate gyrus (DG) transform with experience.
  • To elucidate the roles of granule cells (GCs) and mossy cells (MCs) in this developmental process.

Main Methods:

  • Recorded neuronal activity from putative GCs and MCs in the DG of mice over 27 days.
  • Mice repeatedly traversed a sequence of objects on a treadmill.
  • Developed a competitive learning model of the DG to simulate observed transformations.

Main Results:

  • GCs showed a progressive transformation from sparse encoding of object locations to evenly dispersed place fields.
  • MCs demonstrated minimal transformation and preferentially encoded object locations.
  • The computational model reproduced GC transformations through integration of spatial inputs and required MC-mediated inhibition for even distribution.

Conclusions:

  • Granule cells slowly encode conjunctions of object and spatial information via competitive learning.
  • Mossy cells play a crucial role in homogenizing GC spatial representations, contributing to stable environmental mapping.