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[Dynamics of drug resistance in Proteus mirabilis cultures 1970-1985]
Abstract:
Resistance of 669 clinical strains of Proteus mirabilis to 18 chemotherapeutic drugs was studied in dynamics within 1970-1985. An increase in the number of cultures resistant to ampicillin and carbenicillin was noted while the number of cultures resistant to cephalosporines did not change. Within the period from 1970 to 1975 there was observed a marked increase in the number of Proteus strains resistant to aminoglycoside antibiotics. After that period their number gradually lowered and in 1985 reached the level of 1970. Beginning from 1973 there were observed a decrease in the number of Proteus chloramphenicol resistant strains and simultaneous occurrence of cultures sensitive to this antibiotic. The predominating number of the tested strains preserved during the whole observation period their resistance to tetracycline, doxycycline, rifampicin, novobiocin, furazolidone and furagin. No increase in the number of Proteus strains with multiple drug resistance including those resistant to 5-7 drugs was noted in the observation periods of 1970-1975, 1980 and 1985. The most frequent were Proteus strains resistant to 2-4 drugs. Among them cultures resistant to chloramphenicol and aminoglycoside antibiotics of the first generation predominated. Grouping of the strains by the same resistance spectra provided dividing the rested cultures of Proteus mirabilis into 69 variants.
Insights
Antimicrobial resistance in Proteus mirabilis strains showed dynamic changes between 1970-1985. While resistance to ampicillin increased, chloramphenicol resistance decreased, with many strains remaining susceptible to other drugs.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Proteus mirabilis is a significant opportunistic pathogen.
- Understanding antimicrobial resistance patterns is crucial for effective treatment.
- Longitudinal studies are needed to track evolving resistance trends.
Purpose of the Study:
- To investigate the dynamics of antimicrobial resistance in clinical Proteus mirabilis strains over a 15-year period (1970-1985).
- To identify trends in resistance to 18 different chemotherapeutic drugs.
- To characterize patterns of multidrug resistance in Proteus mirabilis.
Main Methods:
- Retrospective analysis of antimicrobial susceptibility testing data.
- Inclusion of 669 clinical isolates of Proteus mirabilis.
- Monitoring resistance profiles over specified intervals between 1970 and 1985.
Main Results:
- Increased resistance to ampicillin and carbenicillin was observed.
- Resistance to cephalosporins remained stable.
- A transient increase in aminoglycoside resistance was followed by a decrease.
- Decreased chloramphenicol resistance and increased sensitivity were noted.
- High levels of resistance to tetracycline, doxycycline, rifampicin, novobiocin, furazolidone, and furagin persisted.
- No increase in strains resistant to 5-7 drugs; most frequent resistance was to 2-4 drugs.
- Proteus strains were categorized into 69 distinct resistance variants.
Conclusions:
- Proteus mirabilis exhibits dynamic antimicrobial resistance patterns.
- Specific antibiotics like ampicillin and carbenicillin show increasing resistance.
- A significant proportion of strains maintained stable resistance to certain drug classes.
- The study identified key resistance profiles and variants within Proteus mirabilis populations.