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Updated: Dec 9, 2025
10:00
High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
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Type I interferons and related pathways in cell senescence.
Steven M Frisch1, Ian P MacFawn1
1Department of Biochemistry and WVU Cancer Institute, West Virginia University, Morgantown, West Virginia, USA.
Aging Cell
|September 12, 2020
Summary
Interferons, key immune signaling molecules, and cell senescence, a finite growth arrest, unexpectedly intersect. This review explores their bidirectional relationship, impacting immunity, aging, and disease.
Area of Science:
- Immunology
- Cell Biology
- Aging Research
Background:
- Discovery of interferons (1957) as critical immune signaling molecules.
- Discovery of cell senescence (1961) as a finite, irreversible cell growth arrest.
- Cell senescence linked to organismal aging and has implications for homeostasis and disease.
Purpose of the Study:
- To critically review the bidirectional interplay between type I interferons and cell senescence.
- To highlight the implications of this interplay for health and healthspan.
Main Methods:
- Literature review of landmark discoveries in interferon and senescence research.
- Analysis of studies investigating the interaction between interferons and cellular senescence.
- Synthesis of current understanding of their roles in immunity, aging, and disease.
Main Results:
- Interferons and cell senescence exhibit a complex, bidirectional relationship.
- This interplay influences immune responses, aging processes, and disease states like cancer.
- Understanding this interaction is crucial for advancing health and healthspan.
Conclusions:
- The convergence of interferon and senescence research offers new insights into fundamental biological processes.
- Targeting the interferon-senescence axis may hold therapeutic potential for age-related diseases and cancer.
- Further research is warranted to fully elucidate and exploit this critical biological nexus.
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