Natural history of acute kidney disease in patients with cirrhosis

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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

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Marta Tonon1, Silvia Rosi1, Carmine Gabriele Gambino1

  • 1Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine, University of Padova, Padova, Italy.

Journal of Hepatology
|September 12, 2020
PubMed

Insights

Acute kidney disease (AKD) is common in cirrhosis patients and significantly lowers survival rates. This condition can recur or progress to chronic kidney disease (CKD), increasing mortality.

Area of Science:

  • Nephrology
  • Hepatology
  • Internal Medicine

Background:

  • The 2012 KDIGO guidelines defined acute kidney injury (AKI), acute kidney disease (AKD), and chronic kidney disease (CKD).
  • While AKI in cirrhosis is well-studied, AKD's epidemiology and outcomes remain largely unknown.
  • This study addresses the gap in understanding AKD in patients with cirrhosis.

Purpose of the Study:

  • To determine the prevalence of AKD in patients with cirrhosis.
  • To evaluate the impact of AKD on the clinical course, complications, and survival of these patients.

Main Methods:

  • A cohort of 272 consecutive patients with cirrhosis was enrolled.
  • Clinical and laboratory data were collected at baseline.
  • Patients were followed for outcomes including death, liver transplant, or end of study.

Main Results:

  • 29.4% of patients developed AKD during follow-up.
  • AKD was associated with a significantly lower 5-year survival rate (34.8% vs. 88.8%).
  • Patients with AKD experienced higher rates of cirrhosis complications and hospitalizations.

Conclusions:

  • AKD is a frequent complication in patients with cirrhosis.
  • AKD can be reversible but is prone to recurrence and progression to CKD.
  • AKD significantly worsens morbidity and mortality in cirrhosis patients.
Abstract

Keywords:
AKDComplications of cirrhosisHospitalizationKidney diseaseKidney injury in cirrhosisRenal dysfunction

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