Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:03

Long-term Depression

2.8K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.8K
Long-term Depression01:05

Long-term Depression

32.7K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
32.7K
Long-term Potentiation01:35

Long-term Potentiation

57.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
57.6K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

1.8K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SpaceMed: Immersive interdisciplinary academic training for the future of human space exploration.

Experimental physiology·2026
Same author

Effects of a walk in a residential natural vs. urban environment on objective and subjective stress indicators in mothers and their infants.

Environmental research·2026
Same author

A brief Meaningful Work and Enjoyment Scale (MeWES) for extreme operational environments.

Military psychology : the official journal of the Division of Military Psychology, American Psychological Association·2026
Same author

MRI Goes Mobile: Assessing the Reliability and Repeatability of a Mobile vs. Stationary 1.5 T MRI for Functional Neuroscience Studies.

NMR in biomedicine·2026
Same author

Subgingival microbiota composition is associated with brain health in the general population-the PAROMIND study.

EBioMedicine·2026
Same author

Stable individual differences dominate adult brain volume variation until later life.

Imaging neuroscience (Cambridge, Mass.)·2026

Related Experiment Video

Updated: Dec 9, 2025

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

27.4K

Exercise-induced changes in brain activity during memory encoding and retrieval after long-term bed rest.

Anika Friedl-Werner1, Katharina Brauns2, Hanns-Christian Gunga2

  • 1Charité - Universitätsmedizin Berlin, a corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Physiology, Charitéplatz 1, CharitéCrossOver, Virchowweg 6, 10117 Berlin, Germany; Université de Normandie, INSERM U 1075 COMETE, 14000 Caen, France.

Neuroimage
|September 12, 2020
PubMed
Summary
This summary is machine-generated.

High-intensity exercise during bed rest enhances brain efficiency for memory, despite similar memory performance. Physical inactivity may impair neural function in the hippocampus and parahippocampal gyrus.

Keywords:
Bed restEpisodic memoryExercisePattern separation

More Related Videos

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.3K
Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion
15:57

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion

Published on: May 4, 2011

17.0K

Related Experiment Videos

Last Updated: Dec 9, 2025

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

27.4K
Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.3K
Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion
15:57

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion

Published on: May 4, 2011

17.0K

Area of Science:

  • Neuroscience
  • Exercise Physiology
  • Cognitive Psychology

Background:

  • Episodic memory relies on the hippocampus and parahippocampal gyrus.
  • These brain regions are susceptible to neuroplasticity and cognitive changes from exercise.
  • Prolonged physical inactivity, such as bed rest, can negatively impact cognitive function.

Purpose of the Study:

  • To investigate the effects of high-intensity exercise on episodic memory and its neural basis during prolonged bed rest.
  • To compare brain activity patterns between exercising and non-exercising individuals undergoing bed rest.
  • To understand the neuronal mechanisms underlying memory function in physically inactive states.

Main Methods:

  • A randomized controlled trial involving 22 men undergoing 60 days of bed rest.
  • One group performed high-intensity interval training (HIIT) five to six times weekly.
  • Functional magnetic resonance imaging (fMRI) assessed episodic memory and neural activity before and after bed rest.

Main Results:

  • The non-exercising group showed increased Blood-Oxygen-Level-Dependent (BOLD) signal in the left hippocampus and parahippocampal gyrus compared to the exercising group.
  • No significant difference in mnemonic performance was observed between the groups.
  • These findings suggest greater neuronal efficiency in the exercising group during memory tasks.

Conclusions:

  • High-intensity exercise during bed rest may lead to higher neuronal efficiency in memory-related brain regions.
  • Physical inactivity appears to induce dysfunctional mechanisms in the hippocampus and parahippocampal gyrus.
  • Exercise has a modulating effect on cognitive function, highlighting the adverse implications of sedentary lifestyles for bedridden patients.