Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Localizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026

Same author

Model-based design of subthalamic nucleus neurons using hybrid optimization.

Journal of neurophysiology·2026

Same author

Comprehensive map of axonal pathway activation as a function of subthalamic deep brain stimulation location and parameter settings.

Brain stimulation·2025

Same author

Evaluation of DBS computational modeling methodologies using in-vivo electrophysiology in Parkinson's disease.

Brain stimulation·2025

Same author

Leveraging Functional and Structural Connectomics to Guide Neuromodulation in Epilepsy.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2025

Same author

Evaluation of DBS computational modeling methodologies using in-vivo electrophysiology in Parkinson's disease.

medRxiv : the preprint server for health sciences·2025

Search research articles

Related Experiment Video

Updated: Dec 9, 2025

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Deep brain stimulation of terminating axons.

Kelsey L Bower¹, Cameron C McIntyre¹

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Brain Stimulation

|September 12, 2020

Summary

Terminating axons in the subthalamic region are more excitable to deep brain stimulation (DBS) than fibers of passage. This heightened excitability of terminating axons is consistent across various DBS parameters.

Keywords:

Afferent inputs Anodic Cathodic Hyperdirect pathway Subthalamic nucleus

More Related Videos

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

Related Experiment Videos

Last Updated: Dec 9, 2025

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

Area of Science:

Neuroscience
Computational modeling
Biophysics

Background:

Deep brain stimulation (DBS) of the subthalamic region treats Parkinson's disease motor symptoms.
The subthalamic region contains neurons, fibers of passage, and afferents.
The hyperdirect pathway's afferents may mediate therapeutic effects of subthalamic DBS.

Purpose of the Study:

Quantify axon termination's effect on neural excitability during DBS.
Evaluate how stimulation parameters influence the relative excitability of terminating axons (TAs) versus fibers of passage (FOPs).

Main Methods:

Utilized finite element electric field models of DBS.
Coupled models to multi-compartment cable models of axons.
Calculated activation thresholds for TAs and FOPs under varying stimulation conditions (anodic/cathodic, pulse widths).

Main Results:

Terminating axons consistently showed lower activation thresholds than FOPs.
Short pulse widths amplified the relative excitability of TAs over FOPs.

Conclusions:

Terminating axons exhibit robust hyperexcitability to DBS.
This finding is consistent across varied stimulation and axon model parameters.