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Published on: March 16, 2016
Corticosteroids lead to short-term improvement in cerebral amyloid angiopathy-related inflammation
Torge Rempe1, Carlos Eduardo Vervloet Sollero2, Elsa Rodriguez3
1Dept. of Neurology, University of Florida, College of Medicine, 1600 SW Archer Rd, Gainesville, FL, 32608, US; Dept. of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Background:
Cerebral amyloid angiopathy - related inflammation (CAA-ri) is an uncommon manifestation of CAA.
Methods:
Single-center, retrospective review of all charts with ICD-code I68.0 (CAA) from 2/2/2016-1/1/2020.
Results:
Of 152 CAA cases, 13 (8.6%) were consistent with CAA-ri. Corticosteroid-treatment led to short-term reduction in modified Rankin Scale scores (2.6 ± 1.4 vs. 1.6 ± 1.5; p = 0.01) and T2/FLAIR lesion volume (78.1 ± 52.2 cm3 vs. 30 ± 30.9 cm3, p < 0.01) as well as short-term improvement in post-treatment Clinical Global Impression - Global Change scores compared to pre-treatment scores (clinical: 6 ± 1 vs. 2.6 ± 1.3, p = 0.03; radiological: 4.6 ± 1.9 vs. 1.2 ± 0.4, p = 0.03).
Interpretation:
Corticosteroid-treatment leads to clinical and radiological short-term improvement (class IV evidence).
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