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Chitooligosaccharides for wound healing biomaterials engineering.

Hafez Jafari1, Katrien V Bernaerts2, Gianina Dodi3

  • 1BioMatter-Biomass Transformation Lab (BTL), École Polytechnique de Bruxelles, Université Libre de Bruxelles, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050 Brussels, Belgium.

Materials Science & Engineering. C, Materials for Biological Applications
|September 13, 2020
PubMed
Summary

Chitooligosaccharides (CHOS) show potential in medicine and food due to their bioactivities. This review highlights CHOS

Keywords:
Anti-inflammatoryAntibacterial and antifungalAntioxidantChitooligosaccharideImmunostimulatoryPhysicochemical propertiesWound healing, in vitro and in vivo studies

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Area of Science:

  • Biomaterials Science
  • Biochemistry
  • Regenerative Medicine

Background:

  • Chitooligosaccharides (CHOS) are derived from chitin/chitosan.
  • CHOS possess water-solubility and non-cytotoxicity.
  • They exhibit diverse bioactivities including antibacterial, anti-inflammatory, anti-obesity, anti-tumor, and antioxidant properties.

Purpose of the Study:

  • To review the biological activities of CHOS in biomaterials engineering.
  • To focus on CHOS applications in skin tissue healing and regeneration.
  • To provide an overview of CHOS-based wound dressing biomaterials.

Main Methods:

  • Literature review of CHOS biological activities.
  • Analysis of CHOS applications in biomaterials engineering.
  • Synthesis and fabrication of CHOS into wound dressings.

Main Results:

  • CHOS demonstrate significant potential in various medical and food applications.
  • CHOS show promise for enhancing skin tissue healing and regeneration.
  • Fabricated CHOS biomaterials have been evaluated in in vitro and in vivo studies.

Conclusions:

  • CHOS are versatile compounds with broad biological activities.
  • CHOS hold significant promise for advanced biomaterials in regenerative medicine.
  • Further research into CHOS-based wound dressings is warranted.