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A bionic shuttle carrying multi-modular particles and holding tumor-tropic features.

Claudia Borri1, Martin Albino2, Claudia Innocenti3

  • 1Istituto di Fisica Applicata "Nello Carrara", Consiglio Nazionale delle Ricerche, Via Madonna del Piano 10, 50019 Sesto Fiorentino, FI, Italy.

Materials Science & Engineering. C, Materials for Biological Applications
|September 13, 2020
PubMed
Summary

This study introduces bionic shuttles using tumor-tropic macrophages to deliver nanoparticles for cancer nanomedicine. These engineered cells overcome biological barriers, enabling targeted therapy and imaging.

Keywords:
Cobalt ferriteCore-shell nanoparticlesDrug deliveryGoldMacrophages

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Area of Science:

  • Nanomedicine
  • Biotechnology
  • Materials Science

Background:

  • Systemic delivery of nanoparticles faces challenges from biological barriers in cancer nanomedicine.
  • Adaptive cell transfer offers a potential strategy to overcome these barriers and target the tumor microenvironment.

Purpose of the Study:

  • To develop tumor-tropic macrophages as carriers for modular nanoparticles, creating a bionic shuttle for enhanced cancer therapy and imaging.
  • To assess the multifunctionality and targeted delivery capabilities of these bionic shuttles.

Main Methods:

  • Engineered tumor-tropic macrophages to carry magnetic and plasmonic nanoparticles.
  • Characterized the bionic shuttle's plasmonic properties, magnetization, cell viability, and chemotactic activity.
  • Evaluated in vitro applications including magnetic guidance, optical hyperthermia, and photoacoustic imaging.

Main Results:

  • The bionic shuttle integrated up to 40 pg Au per cell and 150 pemu magnetization per cell.
  • Maintained over 90% cell viability and chemotactic activity for at least two days.
  • Demonstrated magnetic guidance (4 μm s-1), stable photothermal conversion (>50°C), and effective photoacoustic imaging.

Conclusions:

  • Bionic shuttles combining macrophages and nanoparticles offer a promising approach to overcome delivery challenges in nanomedicine.
  • This design reconciles multifunctionality and targeted delivery, crucial for advanced cancer therapies.
  • The developed system shows potential for magnetic guidance, hyperthermia, and imaging applications in cancer treatment.