Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

7.6K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
7.6K
Bone Structure01:55

Bone Structure

51.0K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.0K
Bone Remodeling01:40

Bone Remodeling

39.9K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
39.9K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

9.5K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
9.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of oxidative stress-related Xdh gene as a di(2-ethylhexyl)phthalate (DEHP) target and the use of melatonin to alleviate the DEHP-induced impairments in newborn mouse ovaries.

Journal of pineal research·2019
Same author

Biomechanical analysis of the effect of medial meniscus degenerative and traumatic lesions on the knee joint.

American journal of translational research·2019
Same author

Design and biomechanical characteristics of porous meniscal implant structures using triply periodic minimal surfaces.

Journal of translational medicine·2019
Same author

Hypertriglyceridaemia-associated acute pancreatitis: diagnosis and impact on severity.

HPB : the official journal of the International Hepato Pancreato Biliary Association·2019
Same author

Tracking Decitabine Incorporation into Malignant Myeloid Cell DNA in vitro and in vivo by LC-MS/MS with Enzymatic Digestion.

Scientific reports·2019
Same author

RA promotes proliferation of primordial germ cell-like cells differentiated from porcine skin-derived stem cells.

Journal of cellular physiology·2019

Related Experiment Video

Updated: Dec 9, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.0K

Modeling osteoinduction in titanium bone scaffold with a representative channel structure.

Si-Yuan He1, Yun Zhang1, Yin Zhou1

  • 1State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China.

Materials Science & Engineering. C, Materials for Biological Applications
|September 13, 2020
PubMed
Summary

This study models bone ingrowth in porous scaffolds, revealing how pore architecture influences immune cell behavior and osteoinduction. Understanding these mechanisms optimizes implant osteointegration for better bone healing.

Keywords:
Immune regulationMulti-scale modelingOsteoinductionPorous scaffold

More Related Videos

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

11.0K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.4K

Related Experiment Videos

Last Updated: Dec 9, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.0K
Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

11.0K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.4K

Area of Science:

  • Biomaterials Science
  • Computational Biology
  • Tissue Engineering

Background:

  • Optimizing osteointegration of medical implants requires understanding bone ingrowth into porous scaffolds.
  • The mechanisms driving osteoinduction within these scaffolds are complex and involve cellular and molecular interactions.

Purpose of the Study:

  • To develop an immunoregulatory agent-based model to elucidate the osteoinduction mechanism in porous scaffolds.
  • To investigate the role of immune reactions, macrophage polarization, and growth factors in bone ingrowth.

Main Methods:

  • An agent-based model was created incorporating immunoreaction, macrophage polarization (M1/M2 phenotypes), and growth factor signaling.
  • Angiogenesis was included in the model.
  • Model predictions were validated against published in vivo experimental data.

Main Results:

  • The model accurately predicted bone ingrowth patterns observed in vivo.
  • Scaffold pore architecture significantly influenced chemotactic factor diffusion, cellular reactions, and osteoinduction location.
  • Flexural pore spaces showed peripheral bone formation due to M2 macrophage populations, while straight channels allowed deeper osteoinduction.

Conclusions:

  • Scaffold design critically impacts bone ingrowth by modulating immune cell responses and growth factor distribution.
  • The developed model provides insights into optimizing porous scaffold architecture for enhanced osteointegration and bone regeneration.