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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Candida nivariensis: Identification strategy in mycological laboratories
N Cartier1, A Chesnay2, D N'diaye3
1Parasitologie - mycologie - médecine tropicale, CHRU de Tours, 37044 Tours, France.
Journal De Mycologie Medicale
|September 13, 2020
Summary
Candida nivariensis, a rare fungal species, can cause deep-seated infections. Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry is crucial for accurate identification and guiding treatment against antifungal resistance.
Area of Science:
- Medical Mycology
- Clinical Microbiology
Background:
- Candida nivariensis is a cryptic fungal species within the Candida glabrata complex, first identified in 2005.
- Cryptic species pose identification challenges in clinical settings.
Observation:
- A rare case of deep-seated Candida nivariensis infection in a 77-year-old male post-cysto-prostatectomy is presented.
- Initial phenotypic testing suggested Candida glabrata, highlighting potential misidentification.
- The isolate exhibited resistance to fluconazole, a common antifungal agent.
Findings:
- Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry accurately identified Candida nivariensis.
- This case underscores the importance of advanced identification techniques for cryptic fungal species.
- MALDI-TOF MS demonstrated high efficacy in characterizing this challenging isolate.
Implications:
- Accurate identification of Candida nivariensis is essential for appropriate patient management.
- Awareness of fluconazole resistance in C. nivariensis is critical for treatment selection.
- MALDI-TOF mass spectrometry offers a reliable method for identifying rare and cryptic Candida species in clinical laboratories.
