Related Experiment Video
Updated: Jul 18, 2026
09:56
Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions
Published on: August 12, 2010
Eosinophilic granuloma of bone
1Department of Orthopaedics, University of British Columbia, Vancouver.
Summary
Eosinophilic granuloma, a bone disease, is often self-limiting in its solitary form. It can progress to multifocal disease or Hand-Schüller-Christian syndrome, with its immunologic basis still under investigation.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Eosinophilic granuloma is a rare bone disorder.
- It is part of the spectrum of Langerhans cell histiocytosis.
- Historical classifications include Hand-Schüller-Christian syndrome.
Purpose of the Study:
- To review the historical development, treatment, and outcomes of eosinophilic granuloma.
- To evaluate the role of scintigraphic imaging in diagnosis and management.
- To analyze patient data from the University of British Columbia Bone Tumour Registry.
Main Methods:
- Retrospective review of 48 patients with eosinophilic granuloma.
- Analysis of treatment strategies and patient outcomes.
- Inclusion of comments on scintigraphic imaging findings.
Main Results:
- Solitary eosinophilic granuloma is typically self-limiting and requires no intervention.
- Multifocal disease and Hand-Schüller-Christian syndrome represent progressive forms.
- Scintigraphic imaging plays a role in evaluating the extent of disease.
Conclusions:
- Eosinophilic granuloma management depends on its clinical presentation (solitary vs. multifocal).
- Early diagnosis and monitoring are crucial for progressive forms.
- Further research into the immunologic basis of eosinophilic granuloma is warranted.
Related Concept Videos
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:17Gross Anatomy of Bone
The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
01:09Spongy Bone
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
01:28Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:12Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...