A Novel Human Diabetes Biomarker Recognition Approach Using Fuzzy Rough Multigranulation Nearest Neighbour Classifier...

The selection of gene identifier from microarray databases is a challenging task since microarray contains large number of gene attributes for a few samples. This article proposes a novel fuzzy-rough set-based gene expression features selection using fuzzy-rough reduct under multi-granular space for human diabetes patient. Firstly, fuzzy multi-granular gain has been computed from the expression datasets via fuzzy entropy which reduces the dimension of the database. Thereafter, the features have been selected from microarray using the fuzzy rough reduct and information gain with respect to their expression patterns. To reduce the computational cost, a decision making scheme has been designed using a rough approximation of a fuzzy concept in the field of multi-granulation framework. Finally, we have recognized the association among the genomes that have expressively different expression patterns from controlled state to the diabetic state with respect to their impression using modified fuzzy-rough nearest neighbour classifier (FRNNC). Five standard diabetic microarray datasets have been considered to quantify the efficiency of the designed FRNNC model and are validated with F measure using diabetes gene expression NCBI database and it performs superior compared to existing methods.