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Updated: Dec 9, 2025

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
Published on: December 1, 2023
When a T cell engages a B cell: novel insights in multiple sclerosis
Ivan Jelcic1, Mireia Sospedra1, Roland Martin1
1Neuroimmunology and MS Research Section (nims), Neurology Clinic, University of Zurich, University Hospital Zurich, Switzerland.
Abstract:
Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) in which autoreactive T cells are considered to be the major effector cells in orchestrating and promoting CNS injuries. However, B cells emerged as additional important cellular player in multiple sclerosis immunopathogenesis since B cell depletion therapy has been found to be very effective in reducing new relapses. This short review summarises important new insights into the interaction between these two cell populations and outlines recent observations regarding how memory B cells activate brain-homing autoreactive T cells in multiple sclerosis.
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