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Chronic Kidney Disease in Iran: First Report of the National Registry in Children and Adolescences

Neamatollah Ataei1, Abbas Madani2, Seyed Taher Esfahani2

  • 1Pediatric Chronic Kidney Disease Research Center, Department of Pediatric Nephrology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran . ataiinem@tums.ac.ir.

Urology Journal
|September 13, 2020
PubMed

Insights

This study reveals that congenital anomalies of the kidney and urinary tract (CAKUT) are the primary cause of chronic kidney disease (CKD) in Iranian children. Pediatric CKD incidence and prevalence in Iran are lower than in Europe, with high long-term survival rates.

Area of Science:

  • Pediatric Nephrology
  • Epidemiology
  • Public Health

Background:

  • Chronic kidney disease (CKD) in children requires understanding epidemiological factors for early detection and management.
  • Identifying causes and prognosis is vital for improving outcomes in pediatric CKD patients.

Purpose of the Study:

  • To describe the epidemiological characteristics of childhood CKD in Iran.
  • To provide data for early recognition, identification of reversible causes, and prognosis of pediatric CKD.

Main Methods:

  • Cross-sectional study conducted from 1991 to 2009.
  • Data collected from the Iranian Pediatric Registry of Chronic Kidney Disease (IPRCKD) core dataset.
  • Analysis of 1247 registered children with CKD.

Main Results:

  • Mean age at registration was 0.69 years; mean follow-up was 7.19 years.
  • Mean annual incidence of CKD stages 2-5 was 3.34 per million, and prevalence was 21.95 per million.
  • Congenital anomalies of the kidney and urinary tract (CAKUT) were the leading cause (40.01%), followed by glomerulopathy (19.00%).
  • 1-, 5-, and 10-year survival rates were 98.3%, 90.7%, and 84.8%, respectively.

Conclusions:

  • Pediatric CKD incidence and prevalence in Iran are lower compared to European data.
  • CAKUT is the primary etiology, necessitating early urological intervention for renal function preservation.
  • Long-term survival rates for pediatric CKD in this cohort exceed those reported in existing literature.
Abstract

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