Implications of cellular metabolism for immune cell migration
Related Experiment Video
Updated: Dec 9, 2025

Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration
Published on: May 24, 2024
Hannah Guak1,2, Connie M Krawczyk2
1Department of Physiology, McGill University, Montreal, QC, Canada.
Abstract:
Cell migration is an essential, energetically demanding process in immunity. Immune cells navigate the body via chemokines and other immune mediators, which are altered under inflammatory conditions of injury or infection. Several factors determine the migratory abilities of different types of immune cells in diverse contexts, including the precise co-ordination of cytoskeletal remodelling, the expression of specific chemokine receptors and integrins, and environmental conditions. In this review, we present an overview of recent advances in our understanding of the relationship of each of these factors with cellular metabolism, with a focus on the spatial organization of glycolysis and mitochondria, reciprocal regulation of chemokine receptors and the influence of environmental changes.
Related Concept Videos
Cell Migration
Cell Migration
Chemotaxis and Direction of Cell Migration
Cytoskeletal Coordination in Cell Migration
Role of Myosin in Cell Migration
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....

