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Related Experiment Video

Updated: Dec 9, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Risk Factors for Rhinosinusitis After Endoscopic Transsphenoidal Adenomectomy.

Clara H Lee1, Allison K Ikeda2, Shubham Patel1

  • 1Emory University School of Medicine, Atlanta, Georgia.

American Journal of Rhinology & Allergy
|September 14, 2020
PubMed
Summary

Preoperative sinonasal disease does not definitively predict postoperative rhinosinusitis (PRS) after endoscopic transsphenoidal adenomectomy (eTSA). A history of prior sinonasal surgery warrants further investigation as a potential risk factor for PRS.

Keywords:
pituitarypostoperative infectionrhinosinusitissinusitistranssphenoidal

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Area of Science:

  • Otolaryngology
  • Neurosurgery
  • Endocrinology

Background:

  • Endoscopic transsphenoidal adenomectomy (eTSA) for pituitary tumors carries a risk of postoperative complications, including rhinosinusitis.
  • Identifying preoperative risk factors for postoperative rhinosinusitis (PRS) is crucial for patient management.

Purpose of the Study:

  • To investigate whether preoperative sinonasal disease is a risk factor for developing postoperative rhinosinusitis (PRS) following eTSA.
  • To analyze various patient-reported, radiographic, and endoscopic sinonasal factors as potential predictors of PRS.

Main Methods:

  • Retrospective review of 987 patients who underwent eTSA between 2007-2016 at a tertiary academic center.
  • Matched analysis comparing patients with PRS to those without, considering sex, age, tumor size, reconstruction methods, and concurrent septoplasty.
  • Statistical analysis of preoperative sinonasal factors, including patient history, symptoms, radiographic findings, and endoscopic evaluation.

Main Results:

  • 49 of 987 patients (4.96%) developed PRS.
  • A history of prior sinonasal surgery was more common in the PRS group (25.5% vs. 6.5%, p=0.01) but this association was not significant in multivariate analysis.
  • No significant differences were found in the history of sinus infections, nasal symptoms, allergies, radiographic abnormalities, or endoscopic findings between PRS and non-PRS groups.

Conclusions:

  • Preoperative sinonasal disease, as assessed in this study, did not emerge as a definitive risk factor for PRS after eTSA.
  • Further research is warranted to explore the role of prior sinonasal surgery as a potential risk factor for PRS.