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Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Antihypertensive Drugs: Direct Renin Inhibitors01:25

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The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
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Related Experiment Video

Updated: Dec 9, 2025

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
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Renal Denervation: History and Current Status.

David P Lee1

  • 1Stanford University Interventional Cardiology, Room H-2103, 300 Pasteur Drive, Stanford, CA 94305, USA.

Interventional Cardiology Clinics
|September 14, 2020
PubMed
Summary

Renal denervation, initially explored for hypertension, faced setbacks but has regained clinical momentum. Future applications may extend beyond treating high blood pressure.

Area of Science:

  • Cardiovascular medicine
  • Interventional cardiology
  • Nephrology

Background:

  • The review traces the historical development of renal denervation.
  • It covers the conceptualization and early technological advancements, including percutaneous catheter systems.
  • Initial focus was on treating hypertension, driven by early animal and human studies.

Purpose of the Study:

  • To provide a comprehensive historical overview of renal denervation.
  • To analyze the evolution of renal denervation from concept to clinical application.
  • To discuss the impact of pivotal trials and emerging clinical evidence.

Main Methods:

  • Literature review of early conceptualization, technological development, and clinical trials.
  • Analysis of historical data from animal experiments and human studies.
Keywords:
CatheterHypertensionRenal denervation

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  • Examination of pivotal trial outcomes and subsequent clinical trial data.

    • Main Results:

    • Early excitement for renal denervation in hypertension was tempered by a disappointing pivotal trial.
    • Lessons learned from this trial have driven progress, leading to new successful clinical trials.
    • Renal denervation is regaining clinical momentum and demonstrating efficacy.

    Conclusions:

    • Renal denervation has evolved significantly from its early stages.
    • Despite initial challenges, the procedure shows promise for hypertension management.
    • The future potential of renal denervation may encompass applications beyond hypertension treatment.