Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

699
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
699
Lineage Commitment01:21

Lineage Commitment

3.9K
Commitment is the  process whereby stem cells:
3.9K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.7K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.7K
Hematopoiesis01:21

Hematopoiesis

7.9K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
7.9K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.6K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.6K
Production of Formed Elements01:34

Production of Formed Elements

3.3K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Procr+ endothelial progenitor cells govern hematopoiesis through fine-tuning mesenchymal stem cell niche signals.

Blood·2026
Same author

Highlighting the contributions of Professor T. Ray Bradley to ISEH and the field of Experimental Hematology.

Experimental hematology·2026
Same author

Hematopoietic stem and progenitor cell hierarchy is established by thrombopoietin-driven neonatal hematopoiesis.

Stem cell reports·2026
Same author

The Cyclin C-CDK8/19 Mediator kinase module controls PRCC-TFE3 driven senescence in renal epithelium and tumorigenesis in TFE3-RCC.

Neoplasia (New York, N.Y.)·2026
Same author

Genetically Engineered Human iPS Cell-Derived Kidney Organoid Recapitulates an Early Stage of ALK Fusion Gene-Associated Renal Tumorigenesis.

Molecular cancer research : MCR·2025
Same author

Prospective isolation of mouse and human hematopoietic stem cells using PLXDC2.

Communications biology·2025

Related Experiment Video

Updated: Dec 9, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

13.6K

Bone Marrow Transplantation Dynamics: When Progenitor Expansion Prevails.

Ayako Nakamura-Ishizu1, Shah Adil Ishtiyaq Ahmad2, Toshio Suda3

  • 1Department of Microscopic and Developmental Anatomy, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.

Trends in Cell Biology
|September 14, 2020
PubMed
Summary

Hematopoietic stem cell (HSC) transplantation is key for treating blood disorders. Dong et al. used single-cell analysis to reveal how HSCs change after bone marrow transplantation, impacting patient outcomes.

Keywords:
bone marrow transplantationclonal dynamicshematopoietic stemprogenitors

More Related Videos

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

15.7K
Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
10:25

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

Published on: August 9, 2019

9.8K

Related Experiment Videos

Last Updated: Dec 9, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

13.6K
Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

15.7K
Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
10:25

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

Published on: August 9, 2019

9.8K

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Genomics

Background:

  • Hematopoietic stem cell (HSC) transplantation is a critical therapy for various hematologic malignancies and bone marrow failure syndromes.
  • Successful engraftment and sustained hematopoiesis post-transplantation are vital for patient survival and long-term prognosis.
  • Understanding the dynamic behavior and fate of transplanted HSCs is essential for optimizing treatment strategies.

Purpose of the Study:

  • To investigate the dynamic changes in hematopoietic stem cell (HSC) fate following bone marrow transplantation.
  • To elucidate the kinetics and cellular processes governing HSC engraftment and recovery.
  • To provide insights into the molecular mechanisms underlying HSC behavior in the post-transplant environment.

Main Methods:

  • Utilized single-cell transcriptomic analysis to profile HSCs at a high resolution.
  • Employed computational methods to analyze gene expression patterns and infer cellular states.
  • Tracked the temporal evolution of HSC populations after transplantation in a relevant model.

Main Results:

  • Identified distinct trajectories of HSC differentiation and self-renewal post-transplantation.
  • Characterized specific gene expression signatures associated with successful HSC engraftment.
  • Revealed dynamic shifts in cellular signaling pathways influencing HSC fate decisions.

Conclusions:

  • Single-cell transcriptomics offers a powerful approach to dissecting HSC dynamics after transplantation.
  • The study provides a detailed map of HSC fate decisions, crucial for understanding engraftment.
  • Findings may inform the development of novel strategies to improve HSC transplantation efficacy and patient outcomes.