Related Experiment Videos
[Anaphylactic reaction to human insulin. Successful desensitization]
C Wintermantel1, N Fischer, P H Müller
1Medizinische Klinik und Poliklinik, Universität Tübingen sowie III.
Deutsche Medizinische Wochenschrift (1946)
|July 15, 1988
Summary
A patient with type II diabetes developed allergic reactions to porcine and human insulins. Successful treatment involved hyposensitization for immediate-type allergy to multiple insulin species.
Area of Science:
- Endocrinology
- Allergology
- Pharmacology
Background:
- A 48-year-old woman with type II diabetes mellitus experienced poor glycemic control requiring insulin therapy.
- Initial treatment with porcine insulin led to injection site infiltrates, prompting a switch to human insulin.
Observation:
- The patient developed an anaphylactic reaction within minutes after the third injection of human insulin.
- A history revealed brief exposure to bovine insulin during a pregnancy in 1968.
Findings:
- Diagnostic tests confirmed an immediate-type allergy to all three tested insulin species: porcine, bovine, and human.
- The patient's allergic reactions were successfully managed through hyposensitization therapy.
Implications:
- This case highlights the potential for severe allergic reactions to various insulin preparations in diabetic patients.
- Successful hyposensitization offers a viable treatment option for patients with multi-species insulin allergies.
- Further research into the immunogenic properties of different insulin formulations is warranted.