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Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
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Quorum Quenching: A Potential Target for Antipseudomonal Therapy

Fatemeh Hemmati1,2, Roya Salehi3, Reza Ghotaslou4

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Infection and Drug Resistance
|September 14, 2020
PubMed

Insights

Antibiotic resistance in Pseudomonas aeruginosa necessitates new treatments. Quorum sensing inhibitors offer a promising alternative to combat these persistent infections and reduce mortality.

Area of Science:

  • Microbiology and Infectious Diseases
  • Pharmacology and Drug Discovery
  • Bacterial Pathogenesis

Background:

  • Increasing antibiotic resistance in Pseudomonas aeruginosa (P. aeruginosa) poses a global health threat.
  • P. aeruginosa biofilms contribute to severe infections, elevated antibiotic resistance, and higher mortality rates.
  • Current antibiotic treatments are often ineffective against P. aeruginosa infections, especially those involving biofilms.

Purpose of the Study:

  • To review natural and synthetic quorum sensing inhibitors (QSIs) targeting P. aeruginosa.
  • To assess current understanding of quorum sensing (QS) mechanisms in P. aeruginosa.
  • To evaluate various quorum quenching (QQ) strategies for controlling P. aeruginosa virulence.

Main Methods:

  • Comprehensive literature review of research on QSIs and QQ strategies for P. aeruginosa.
  • Analysis of studies detailing QS mechanisms and their inhibition.
  • Assessment of the efficacy of different natural and synthetic QSIs and QQ approaches.

Main Results:

  • Quorum sensing inhibitors (QSIs) and quorum quenching (QQ) are identified as potential therapeutic alternatives or adjuncts.
  • QSIs can modulate P. aeruginosa virulence factors, aiding host immune clearance.
  • A range of natural and synthetic QSIs have been reported, showing promise in preclinical studies.

Conclusions:

  • QSIs and QQ strategies represent a novel approach to combatting P. aeruginosa infections.
  • These agents can overcome antibiotic resistance by targeting virulence rather than bacterial viability.
  • Further research into QSIs and QQ is crucial for developing effective treatments against difficult-to-treat P. aeruginosa infections.
Keywords:
Pseudomonas aeruginosananoparticlenatural compoundsquorum quenchingsquorum sensingsynthetic compounds

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