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Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke

Cameron Lenahan1,2, Lei Huang2,3,4, Zachary D Travis2,5

  • 1Burrell College of Osteopathic Medicine, Las Cruces, NM 88003 USA.

Chinese Neurosurgical Journal
|September 14, 2020
PubMed

Insights

Scavenger Receptor Class B type 1 (SR-B1) may offer new stroke therapies by targeting key risk factors like hypertension and diabetes. Understanding SR-B1

Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Immunology

Background:

  • Stroke is a leading cause of death with a decreasing age of incidence.
  • Novel therapeutic targets are needed for stroke prevention and treatment.
  • Scavenger Receptor Class B type 1 (SR-B1) is a cell surface protein with anti-inflammatory and anti-atherosclerotic properties.

Purpose of the Study:

  • To review the characteristics of SR-B1.
  • To explore the correlation between SR-B1 and modifiable stroke risk factors.

Main Methods:

  • Literature review of SR-B1 function.
  • Analysis of SR-B1's interaction with stroke risk factors.

Main Results:

  • SR-B1 plays a role in reducing inflammation and atherosclerosis.
  • SR-B1 is implicated in the pathogenesis of stroke via modifiable risk factors.

Conclusions:

  • SR-B1 presents a potential therapeutic target for stroke.
  • Modulating SR-B1 activity could mitigate risks associated with smoking, diabetes, diet, obesity, hypertension, and hypercholesterolemia.

Keywords:
AtherosclerosisCoronary heart diseaseDiabetes mellitusHypercholesterolemiaHypertensionObesityPhysical inactivitySR-B1Scavenger Receptor Class B type 1Sickle cell

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