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Full-range space-division multiplexing optical coherence tomography angiography.

Yongyang Huang1, Jason Jerwick1,2, Guoyan Liu1,3

  • 1Department of Electrical and Computer Engineering, Lehigh University, 19 Memorial Drive West, Bethlehem, PA 18015, USA.

Biomedical Optics Express
|September 14, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a full-range space-division multiplexing optical coherence tomography (FR-SDM-OCT) system capable of imaging >20mm deep in tissue. This advancement enables high-quality, wide-field, label-free angiography of in vivo tissues.

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Area of Science:

  • Biomedical Optics
  • Optical Imaging
  • Medical Technology

Background:

  • Space-division multiplexing optical coherence tomography (SDM-OCT) traditionally faces limitations in imaging depth.
  • Achieving long depth measurement ranges in SDM-OCT is crucial for separating multiple images from different sample locations.

Purpose of the Study:

  • To develop and demonstrate a full-range space-division multiplexing optical coherence tomography (FR-SDM-OCT) system.
  • To extend the imaging range of SDM-OCT systems and suppress complex conjugate terms.
  • To validate the system's feasibility for imaging biological tissues and performing angiography.

Main Methods:

  • Utilized a galvanometer-based phase modulation full-range technique.
  • Achieved a digitizer sampling rate of 500 MS/s and a laser sweeping rate of 100 kHz.
  • Demonstrated complex conjugate term suppression up to ~46 dB at 1.4 mm and ~30 dB at 19.4 mm depth.

Main Results:

  • The FR-SDM-OCT system achieved an imaging range exceeding 20 mm in tissue.
  • Complex conjugate terms were effectively suppressed, enhancing image quality.
  • Feasibility was validated by imaging Scotch tapes and human fingernails.
  • FR-SDM-OCT angiography (FR-SDM-OCTA) successfully acquired simultaneous angiograms from four positions with a wide field-of-view.

Conclusions:

  • The full-range technique effectively alleviates hardware requirements for long depth measurements in SDM-OCT.
  • FR-SDM-OCTA opens new avenues for label-free, wide-field in vivo tissue angiography.
  • This technology has the potential to advance diagnostic capabilities in various medical fields.