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Fecal Microbiota Transplantation in Recurrent Clostridium Difficile Infection: Is it Superior to Other Conventional

Zayar Lin1, Zafar Iqbal2,3, Juan Fernando Ortiz4

  • 1Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Cureus
|September 14, 2020
PubMed

Insights

Clostridium difficile infection (CDI) is a common hospital-acquired illness. Fecal microbial transplant (FMT) shows high efficacy for recurrent CDI, but more research is needed for its first-line use.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Clostridium difficile (C. difficile) is a gram-positive, spore-forming bacterium.
  • Clostridium difficile infection (CDI) is a leading hospital-acquired infection in the US, often linked to antibiotic-induced intestinal dysbiosis.
  • Recurrent CDI (rCDI) affects approximately 30% of patients within eight weeks of initial treatment.

Purpose of the Study:

  • To review the pathophysiology, risk factors, diagnostics, and treatments for CDI.
  • To evaluate the potential of fecal microbial transplant (FMT) for managing multiple recurrent CDI cases.

Main Methods:

  • Literature review of current research on Clostridium difficile infection.
  • Analysis of diagnostic methods and treatment modalities for CDI.
  • Assessment of fecal microbial transplant efficacy in recurrent CDI.

Main Results:

  • Fecal microbial transplant (FMT) demonstrates a nearly 90% efficacy rate in patients with multiple recurrent CDI.
  • Despite high efficacy, FMT is not widely adopted as a first-line treatment for recurrent CDI.

Conclusions:

  • Fecal microbial transplant (FMT) is a highly effective option for recurrent Clostridium difficile infection.
  • Further studies are required to establish FMT as a standard first-line therapy for recurrent CDI.
Keywords:
clostridium difficile infectionclostridium difficile infection treatmentfecal microbiota transplantation in clostridium difficile infection

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