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Circadian Clock and Complement Immune System-Complementary Control of Physiology and Pathology?
Pooja Shivshankar1, Baharan Fekry2, Kristin Eckel-Mahan2
1Research Center for Immunology and Autoimmune Diseases, Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
Frontiers in Cellular and Infection Microbiology
|September 14, 2020
Summary
Chronic circadian disruption impacts health, affecting the complement immune system. Understanding this link is crucial for developing new treatments for autoimmune and metabolic diseases.
Area of Science:
- Immunology
- Chronobiology
- Molecular Biology
Background:
- Mammalian circadian clocks regulate daily physiological rhythms, synchronized with light-dark cycles.
- Circadian disruption is linked to various health issues, including metabolic disorders, immune dysfunction, and cancer.
- The complement system, crucial for immune response, is increasingly recognized for its role in inflammation and disease.
Purpose of the Study:
- To investigate the intricate relationship between the internal circadian clock and the complement immune system.
- To explore how circadian disruption influences complement factors and inflammatory pathways.
- To understand the feedback mechanisms between circadian regulation and complement activation.
Main Methods:
- Review of epidemiological and controlled studies on circadian rhythms and health outcomes.
- Analysis of evidence linking circadian disruption to inflammatory mediators and oxidative stress.
- Examination of the role of complement factors (C3a, C5a) in immune response and inflammation.
Main Results:
- Circadian disruption can induce dysregulated proinflammatory cytokines and complement factors.
- These disruptions can feedback into circadian gene regulation, impairing host defense.
- The complement system, while vital for immunity, can amplify chronic inflammation and contribute to autoimmune and metabolic diseases.
Conclusions:
- The interplay between circadian rhythms and the complement system is critical for immune homeostasis.
- Dysregulation of this interaction can lead to severe health consequences, including organ failure.
- Further understanding of circadian properties of the complement system may enhance therapeutic strategies for autoimmune and complement-mediated diseases.
Keywords:
autoimmune diseasecircadian systemcomplement immunityhost microbial interactionsinflammation immunomodulationmetabolic diseaseMore Related Videos
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