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Midazolam versus diazepam as premedication for upper gastrointestinal endoscopy: a randomized, double-blind,
G Bianchi Porro1, S Baroni, F Parente
1Gastrointestinal Unit, L. Sacco Hospital, Milan, Italy.
Gastrointestinal Endoscopy
|May 1, 1988
Summary
Midazolam and diazepam offer comparable sedation for upper gastrointestinal endoscopy. Midazolam provides superior amnesia and patient acceptance, making it ideal for repeat procedures.
Area of Science:
- Gastroenterology
- Pharmacology
- Anesthesiology
Background:
- Midazolam and diazepam are commonly used sedatives.
- Their comparative efficacy in gastrointestinal endoscopy requires further investigation.
Purpose of the Study:
- To compare the effectiveness of midazolam versus diazepam as premedication for upper gastrointestinal endoscopy.
Main Methods:
- A double-blind, crossover study was conducted.
- 23 patients undergoing upper gastrointestinal endoscopy participated.
- Sedation, cooperation, recovery, vital signs, amnesia, and patient acceptability were assessed.
Main Results:
- Sedation, cooperation, and recovery were similar between midazolam and diazepam.
- Both drugs had comparable effects on blood pressure and heart rate.
- Midazolam induced significantly greater amnesia (91% vs. 39%) and higher patient acceptability (78% vs. 26%) than diazepam.
Conclusions:
- Midazolam is a preferred agent over diazepam for upper gastrointestinal endoscopy when amnesia is a key consideration.
- Midazolam's superior amnesic properties and patient acceptance benefit patients, particularly for repeat procedures.