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Methylation data of mouse Rb-deficient pineoblastoma
Philip E D Chung1,2, Eldad Zacksenhaus1,2
1Toronto General Research Institute - University Health Network, 67 College Street, Toronto, ON M5G 2M1, Canada.
Data in Brief
|September 14, 2020
Summary
This study presents methylation profiling data from a novel mouse model of pineoblastoma, offering insights into brain cancer epigenetics. The data aids in understanding tumor development and comparing across different brain cancers.
Area of Science:
- Oncology
- Genomics
- Epigenetics
Background:
- Methylation profiling is crucial for studying tumor biology, especially in brain cancers with limited tissue availability.
- Novel mouse models for germ line mutations in pineoblastoma have been developed.
- Pineoblastoma is a rare brain tumor often associated with genetic mutations.
Purpose of the Study:
- To present novel methylation profiling data from a mouse model of pineoblastoma.
- To provide a dataset for inter- and intra-species comparisons with other brain cancers.
- To investigate epigenetic mechanisms in Rb-deficient pineoblastoma development.
Main Methods:
- Methylation profiling was performed on 8 Rb-deleted/p53-deleted pineoblastoma samples from a mouse model.
- 3 normal cerebellum tissues were used as controls.
- Data is publicly accessible via the Sequence Read Archive (SRA) under accession PRJNA638504.
Main Results:
- Generation of a unique methylation dataset for Rb-deficient pineoblastoma.
- Establishment of a control dataset from normal cerebellum tissues.
- The dataset is ready for comparative analyses.
Conclusions:
- The presented methylation data serves as a valuable resource for brain cancer research.
- Enables comparative studies between pineoblastoma subtypes and other brain cancers.
- Facilitates investigation into epigenetic drivers of pineoblastoma-genesis.
