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Multisystem inflammatory syndrome in children: A systematic review
Mubbasheer Ahmed1, Shailesh Advani2,3, Axel Moreira1
1Department of Pediatrics, Texas Children's Hospital, Houston, TX, USA.
Eclinicalmedicine
|September 14, 2020
Summary
Multisystem inflammatory syndrome in children (MIS-C) is a dangerous condition linked to COVID-19. While most children survive with prompt care, long-term outcomes for MIS-C remain unknown.
Area of Science:
- Pediatric critical care medicine
- Infectious diseases
- Public health
Background:
- Multisystem inflammatory syndrome in children (MIS-C) is a severe hyperinflammatory condition associated with COVID-19.
- This syndrome presents a significant challenge in pediatric healthcare due to its novelty and potential severity.
Purpose of the Study:
- To systematically review and describe the clinical presentation, laboratory findings, imaging results, and outcomes of children diagnosed with MIS-C.
- To consolidate current knowledge on MIS-C to aid in its recognition and management.
Main Methods:
- A systematic review of observational studies published between January 1, 2020, and July 25, 2020.
- Searches were conducted across four medical databases, with data extraction and risk of bias assessment performed by two independent reviewers.
- The review was registered with PROSPERO (CRD42020191515).
Main Results:
- The review included 39 studies with 662 MIS-C patients; 71% required intensive care, and 1.7% died.
- Common symptoms included fever (100%), abdominal pain/diarrhea (73.7%), and vomiting (68.3%).
- Significant abnormalities were noted in inflammatory, coagulative, and cardiac markers, with 54% showing abnormal echocardiographs, including depressed ejection fraction in 45.1%.
Conclusions:
- MIS-C is a serious, potentially lethal pediatric illness linked to SARS-CoV-2.
- Prompt medical attention is crucial for survival, but the long-term health consequences of MIS-C are yet to be determined.
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