Related Experiment Video
Updated: Dec 9, 2025
Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
Published on: September 7, 2021
[Genetic analysis of a 45,X male fetus]
Yan Zeng1, Dehua Cheng, Jian Zhao
1Center for Prenatal Diagnosis, Shaoxing Women and Children's Health Care Hospital, Zhejiang 312000, China. 2560336019@qq.com.
Objective:
To analyze the prenatal diagnosis procedure for a 45,X male fetus.
Methods:
A 31-year-old women underwent amniocentesis due to a moderate risk of trisomy 21. The fetal cells were subjected to chromosomal karyotyping, BACs-on-BeadsTM (BoBs) assay, chromosomal microarray analysis and fluorescence in situ hybridization.
Results:
Combined analyses revealed that the whole of Yp has translocated to 21p, which yielded a fetal karyotype of 45,X,dic(Y;21)(q11;p11).ishdic(Y;21)(SRY+,CEPY+;CEP21+).
Conclusion:
BoBs and modified N-banding method are helpful for the diagnosis of 45,X male fetus with Yp translocation.
Related Concept Videos
02:19The Y Chromosome Determines Maleness
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
01:35Pedigree Analysis
02:45The Ratio of X Chromosome to Autosomes
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
02:32X and Y Chromosomes
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
01:15Development of the Sexual Organs in the Embryo and Fetus
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
01:20Genetic Material