Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.1K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

325
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
325
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

331
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
331
Human Genetics01:28

Human Genetics

1.2K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.2K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.6K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Navigating late-life parental care transitions: implications for adult children's psychosocial well-being.

The Gerontologist·2026
Same author

Work expectations, employment patterns, and psychological distress during the Great Recession among older Americans and South Koreans.

The Gerontologist·2025
Same author

Road to Genicular Artery Embolization: Importance of the Anastomotic Network.

Cardiovascular and interventional radiology·2025
Same author

Management of incontinence after classic bladder exstrophy closure.

Actas urologicas espanolas·2025
Same author

Multicentric Angiographic Assessment of the Branching Patterns and Anastomotic Network of the Genicular Arteries, with Implications for Genicular Artery Embolization.

Cardiovascular and interventional radiology·2025
Same author

Psychological Care Needs and Mental Health Service Use Among Adults with Diabetes: Evidence from the Diabetes, Distress, and Disparities (3D) Study.

Healthcare (Basel, Switzerland)·2025

Related Experiment Video

Updated: Dec 9, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.1K

Understanding the relationship between type 2 diabetes and depression: lessons from genetically informative study

R S Bergmans1, A Rapp2, K M Kelly2

  • 1Department of Psychiatry.

Diabetic Medicine : a Journal of the British Diabetic Association
|September 14, 2020
PubMed
Summary

Genetically informed studies show type 2 diabetes may increase depression risk, but not vice versa. Evidence for shared genes or gene-environment interaction in comorbid depression and type 2 diabetes is limited.

More Related Videos

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Published on: April 19, 2013

24.7K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.1K

Related Experiment Videos

Last Updated: Dec 9, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.1K
Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Published on: April 19, 2013

24.7K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.1K

Area of Science:

  • Psychiatry and Endocrinology
  • Genetic Epidemiology

Background:

  • Comorbid depression and type 2 diabetes represent a significant public health challenge.
  • Understanding the etiological relationship between these conditions is crucial for effective prevention and treatment.

Purpose of the Study:

  • To systematically review genetically informative studies examining the relationship between depression and type 2 diabetes.
  • To synthesize evidence regarding causal pathways, shared genetic liability, and gene-environment interactions.

Main Methods:

  • Systematic literature search of PubMed and EMBASE (2008-2020) following PRISMA guidelines.
  • Inclusion of studies utilizing genetically informed designs (twin modeling, Mendelian randomization, GWAS, PRS, LDSC).
  • Analysis of 16 eligible manuscripts from 451 unique citations.

Main Results:

  • Modest evidence suggests type 2 diabetes causally influences depression risk.
  • Limited evidence indicates depression causally influences type 2 diabetes risk.
  • Little evidence supports shared genetic liability or gene-environment interaction between the two conditions.

Conclusions:

  • Genetically informed studies provide mixed findings, with some support for uni- or bi-directional phenotypic causation.
  • Further research should investigate shared environmental risk factors.
  • Findings can inform integrated approaches to managing diabetes and its psychosocial comorbidities.