Related Experiment Video

Updated: Dec 9, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

571

Prevalence of cerebral edema among diabetic ketoacidosis patients

Paula González Pannia1, Romina Balboa2, Rocío Navarro2

  • 1Hospital General de Niños Pedro de Elizalde, Buenos Aires, Argentina. pau.gp@hotmail.com.

Archivos Argentinos De Pediatria
|September 14, 2020
PubMed

Insights

Cerebral edema (CE) affects 1.44% of children with diabetic ketoacidosis (DKA). High urea, low sodium, and low carbon dioxide levels at admission are risk factors for CE development in DKA patients.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Neurology

Background:

  • Cerebral edema (CE) is a severe complication of diabetic ketoacidosis (DKA) in children.
  • The exact pathogenesis of CE in DKA remains unclear.
  • CE onset is often linked to intravenous rehydration during DKA treatment.

Purpose of the Study:

  • To determine the prevalence of CE in pediatric DKA patients.
  • To identify risk factors associated with CE development in DKA patients.

Main Methods:

  • A cross-sectional prevalence study was conducted.
  • Clinical and laboratory data from pediatric DKA patients (aged 1-18) were analyzed.
  • 693 DKA events from 561 medical records (2005-2014) were reviewed.

Main Results:

  • The prevalence of CE among pediatric DKA patients was 1.44%.
  • Patients with CE exhibited higher serum urea levels (p < 0.001).
  • CE patients also showed lower carbon dioxide pressure (p < 0.001) and lower serum sodium levels (p < 0.001).

Conclusions:

  • The prevalence of CE in this study (1.44%) is lower than previously reported in the country (1.8%).
  • Key risk factors for CE at admission include elevated serum urea, hyponatremia, and hypocapnia.
Abstract

Keywords:
cerebral edemachilddiabetes mellitusdiabetic ketoacidosis

More Related Videos

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats08:47

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

11.8K
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

722

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
403
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
558
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.8K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
184
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.8K
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
113